3 overall team, is the biggest favorite at 21.5 points over No. 1 seed Houston in the Midwest Region pop up (unsurprisingly) as the heaviest favorites on the opening slate between First Four and first-round action. 1 Purdue await the winners of the First Four, but No.
1 seeds have officially drawn an opponent. The odds are below for all First Four games and for most of the first round games, save for the opponents awaiting the winner of play-in games. But using handicapped odds and lines should give you a more complete picture to fill out your bracket and give you an edge to win your pool (and, more importantly, bragging rights at the office).
March Madness is known for its unpredictability and randomness, and this year should be no different - so pick upsets and underdogs at your own peril. The fine folks at Caesars Sportsbook then helped complete one of the final pieces of the puzzle necessary to fill out your bracket with betting odds and lines for every single game of the First Four and the first round. The NCAA Tournament selection committee on Sunday revealed its 68-team field for this year's March Madness and seeded every qualifying team from 1-68 in the process.
